A drug of abuse--Mandrax.
نویسنده
چکیده
The first indications of drug abuse were reported within a matter of weeks of Mandrax reaching the market, but due to the widespread abuse of barbiturates they went largely unnoticed. Now the drug is perhaps only second to Mogadon (nitrazepan) as a non-barbiturate sedative/hypnotic in the large quantities prescribed. There are however good reasons why this particular drug combination ought to be prescribed by doctors with the utmost care.
منابع مشابه
Effects of Mandrax and Cannabis on the cellular function of chick embryonic neurons.
Cannabis and Mandrax abuse is unique to South Africa; and most research has focused on the socio-economic impact rather than the adverse effects on the developing brain. Therefore, the aim of this study is to determine the effects of Mandrax and Cannabis alone and in combination on the developing brain by using primary and suspension cultures of the chick embryo brain. Exposure of primary chick...
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The influence of the newer, non-barbiturate hypnotics Mandrax (diphenhydramine-methaqualone) and nitrazepam on drug-metabolizing capacity was assessed and compared with the effect of amylobarbitone, a known inducer of drug-metabolizing enzymes. Plasma antipyrine and phenylbutazone half-lives and urinary output of 6beta-hydroxycortisol were used as indices. Volunteer subjects were exposed to the...
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OBJECTIVE To assess the extent of cannabis and other drug use among patients presenting with recent injuries at trauma units in Cape Town, Port Elizabeth and Durban from 1999 to 2001. DESIGN Cross-sectional surveys were conducted during a 4-week period at each of the above sites in 1999, 2000 and 2001. The concept of an idealised week was used to render representative samples. OUTCOME MEASU...
متن کاملSubstance abuse and major trauma in Johannesburg.
INTRODUCTION The abuse of alcohol and drugs is a major public health problem and intoxication is one of the most important risk factors for violence and other causes of injury. The aim of the current study was to evaluate the prevalence of drug and alcohol use associated with injury in adult trauma patients in an inner city trauma unit in Johannesburg. METHODS A cohort of 105 adult trauma pat...
متن کاملBalanitis due to fixed eruption after Mandrax.
Five cases of balanitis due to fixed eruption after tetracycline therapy were reported by Csonka, Rosedale, and Walkden (1971) and since then a severe recurrent balanitic reaction has been observed in one patient after taking single doses of 'Mandrax' (diphenhydramine-methaqualone). No similar case appears to have been published. Case report An unmarried Caucasian male student, aged 20, attende...
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ورودعنوان ژورنال:
- Journal of the Irish Medical Association
دوره 66 16 شماره
صفحات -
تاریخ انتشار 1973